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NTS1 has also been implicated in sleep and psychiatric disorders which often co-occur with AUD and can increase the proclivity for relapse

Going forward, the company will initiate more than 30 Phase III trials in 2023, ten of which have the potential to deliver sales over $1 billion

Verma, S

J Transl Med 17:55 Tsai SY, Lin CL, Shih SC, Hsu CW, Leong KH, Kuo CF, Lio CF, Chen YT, Hung YJ, Shi L (2018) Increased risk of chronic fatigue syndrome following burn injuries

These studies suggest a dynamic involvement of Irs2 which may be differentially affected across drug (stimulant versus sedative) and knock-out models in the presence or absence of these drugs