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10.3390/ijms24021703 70 NewsomeP
Even if these approaches are successful in many cases, there is still a subset (3%5% of patients) that progress to therapeutically refractive disease, constituting the so-called TC-related deaths due to the lack of effective treatment. In this view, some efforts are ongoing to identify personalized therapy for refractory patients and drug repositioning represents one of the potential alternatives (Xu et al., 2019)
Moreover, the comparison of CRP levels at the different timepoints evaluated did not show any significant differences between the LCLT and placebo groups, as presented in Table 3
