One interesting (and funny) detail is the involvement of a gene pathway called CART, which stands for cocaine- and amphetamine-regulated transcript
This likely reflects enhanced nutrient uptake creating cellular volumization
Drug Metab Dispos 38:16651672 Kato Y, Kubo Y, Iwata D, Kato S, Sudo T, Sugiura T, Kagaya T, Wakayama T, Hirayama A, Sugimoto M, Sugihara K, Kaneko S, Soga T, Asano M, Tomita M, Matsui T, Wada M, Tsuji A (2010) Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1
We have seen patients on both GLP-1s and biologic medications (eg Taltz, Skyrizi) see remarkable improvement in their psoriasis Will My Hidradenitis Suppurativa Improve on GLP-1s
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