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L-Carnitine forms a reversible ester bond with fatty acids, creating acylcarnitine, which is then transported across the inner mitochondrial membrane by specific carrier proteins
Fiona W
Johansen NL et al
To establish the importance of the NEP-derived metabolite GLP-1(2836) to the overall cardiovascular biology of GLP-1, we used sacubitril, a pharmacological inhibitor of NEP, and assessed in vitro cAMP accumulation in caSMCs, as well as functional LVDP recovery in an ex vivo Langendorff model of IRI
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