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Most guidelines recommend discarding after twenty-four to forty-eight hours
and preventing and treating vitamin C deficiency (scurvy)
PLoS One 11 (9), e0162590
As vitamin B12 seems to be better absorbed on an empty stomach (or better yet, acidic environment), you should try to wait for a few hours after having your evening meal before taking them
The held reference package contains the abstract-level publication rather than a full body-composition paper
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