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The FDA does require a boxed warning for GLP-1 receptor agonists (Wegovy, Saxenda) and the dual GIP/GLP-1 receptor agonist tirzepatide (Zepbound) regarding thyroid C-cell tumors, based on rodent studies, though human relevance remains uncertain
It helps alleviate insulin resistance as well as obesity induced by a high-fat diet
It is currently in clinical trials as a treatment option for adults with type 2 diabetes (T2DM) and obesity
Those physiological changes can make it even harder for someone to control their health and weight
The liver has no GLP-1 or GIP receptors but is rich in glucagon receptors, which makes retatrutide an attractive option in the nephrology community
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