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In 2008, this lab reported that an additional complex RAS synthetic lethal 3 (RSL3) induced a similar cell death form, which could be inhibited by iron chelates (Yang and Stockwell, 2008)
Its also used to help prevent bone loss and reduce the risk of osteoporosis in some women
Both of these molecules contribute to defense against oxidative stress (Sies, Berndt, & Jones, 2017), and both have connections to ER protein biogenesis
Plus, the natural hormone breaks down quickly, within minutes, so its effects dont last long unless consistently supported
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