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The CU Anschutz team chose the oral formulation of semaglutide deliberately, as injectable versions of the drug were previously tested for alcohol use disorder and had shown similar effects, but researchers believed a pill would be more acceptable to the patient population
Research protocols that begin at the target dose without escalation may produce confounding adverse effect data
Nausea, vomiting, constipation, diarrhea, and reduced appetite are the most common usually mild and dose-dependent
Given that acid reflux, or gastroesophageal reflux disease (GERD), involves the backflow of stomach acids into the esophagus, leading to discomfort and potential long-term esophageal damage, the concern is valid
Some patients continue therapy for longer periods under medical supervision, while others may decide to stop once they reach specific body composition or wellness goals
