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1999, Respiration, 66(6):518-521
The researchers showed that FOXO4-DRI treatment induced apoptosis specifically in senescent chondrocytes while sparing healthy proliferating cells, confirming the selectivity mechanism described in the original Baar et al
nonetheless, these assertions remain based on preclinical findings
Animal studies have shown it to be cytoprotective against known carcinogens
This results in sustained release, better tissue targeting, stronger mitochondrial protection, and improved redox balance.
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