When nucleoid turnover and endolysosomal disposal are compromised, mtDNA and inner membrane-associated immunostimulatory species accumulate in aberrant location and chronically activate cytosolic DNA sensing and inflammasome pathways, including cGAS-STING and NLRP3 pathway, thereby biasing myeloid and stromal compartments toward type I interferon and IL-1 family responses (144,157,158)
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Nguyen TD, Shingu Y, Amorim PA, Schenkl C, Schwarzer M, Doenst T
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