heartburn with tirzepatide Side Effects: How Zepbound & Mounjaro Affect Digestion why does tirzepatide cause heartburn

doi: 10.1016/j.pneurobio.2005.06.004 78 MrakREGriffinWST

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Patients should eat slowly and stop when comfortably satisfied rather than completely full, as tirzepatide's effects on gastric emptying can cause discomfort with overeating

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It describes the wider adverse-event profile as dominated by digestive symptoms, with nausea first, then vomiting, constipation, diarrhea, and abdominal discomfort