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This efficient recycling mechanism helps maintain adequate B12 levels over extended periods

PFIC2 PFIC2 is caused by variants in the ABCB11 gene, which encodes the bile salt export pump (BSEP), the primary transporter of BAs from hepatocytes to the canalicular lumen

Most participants who experienced nausea during the initial titration phase reported significant improvement or complete resolution by weeks 4 to 8 at a stable dose

GSK3 phosphorylation catalyzes the aggregation of tau into alzheimers disease-like filaments

They can evaluate dosing, lifestyle factors, medical conditions, medication adherence, and whether another treatment approach may be more effective.