It can also affect B12 absorption
Additionally, gastrointestinal side effects including nausea, vomiting, and diarrhoeaare common with GLP-1 medications and can contribute to tiredness through dehydration and reduced food intake
Br J Clin Pharmacol 2025 co-infused a GLP-1 agonist with glucagon in healthy young men (Part B, n=12, median age 24): exenatide alone +4 bpm (95% CI 26), low-dose glucagon alone +4 bpm (95% CI 17), and the two together +7 bpm (95% CI 49) at 60 min
However, not everyone notices immediate changes
Nevertheless, professional guidance is crucial before incorporating B6, B12, or semaglutide into a weight management plan, as a healthcare provider can offer personalized recommendations