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The anti-PD-L1 serves dual functions: it targets the nanoparticles to PD-L1-expressing tumor cells and simultaneously blocks the PD-1/PD-L1 interaction to prevent T cell exhaustion

The target and the pathway in more detail The GLP-1 receptor is a class B1 G-protein-coupled receptor with a large extracellular domain that captures the C-terminal half of the ligand before the N-terminal half inserts into the transmembrane bundle

Periodic maintenance treatments can help support continued weight control

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Contrast With Traditional Diabetes Medications The weight effects of GLP-1 medications contrast sharply with older diabetes treatments: Insulin: Typically causes weight gain of 4-8 pounds over the first year, sometimes more