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Individuals have a higher risk of gaining the weight back if they do not keep up with the healthy lifestyle changes they made

Even melatonin, a hormone with strong antioxidant properties that accumulates in mitochondria, has been shown to reduce organ injury in various IR models and has been trialed in liver surgery context as a hepatoprotective (with some positive results in reducing transaminase release) (111)

Uncontrolled High Blood Pressure Contrave can increase blood pressure which is an issue for those with a history of uncontrolled high blood pressure

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The ability to drive may also be affected by fluctuations in blood sugar