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GLP-1 receptor agonists have shown consistent benefit in PCOS: a 2022 meta-analysis in Human Reproduction Update (N=10 trials, 484 women) found that GLP-1 agonist therapy reduced fasting insulin by 1.98 mIU/L, total testosterone by 0.19 nmol/L, and improved menstrual regularity in 55% of participants [10]

T2DM generates an environment prone to atherogenesis

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Beyond Lactobacillus and Bifidobacterium , several other taxonomic groups demonstrate significant therapeutic and industrial value ( Table 2 )