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Given the US population distribution, the greatest number of persons with these benefits will occur in White, followed by Black, Hispanic, and Asian persons

Study design factors: This was a single-dose study at 5mg

Peptides were separated by chromatography with the following parameters: Acclaim PepMap100 C18 pre-column (2 cm, 75 m i.d., 3 m, 100 ), Pepmap-RSLC Proxeon C18 column (75 cm, 75 m i.d., 2 m, 100 ), 300 nl/min flow rate, using a gradient rising from 95% solvent A (water, 0.1% formic acid) to 40% B (80% acetonitrile, 0.1% formic acid) in 120 min, followed by a column regeneration of 20 min, for a total run of 140 min

The dose may be increased in 2.5 mg increments every four weeks based on glycemic response and tolerability, up to a maximum of 15 mg weekly

These differences support a potentially complementary therapeutic strategy in patients with overlapping HF, metabolic, and atherosclerotic risk