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Key points: GLP-1 receptor agonists may protect the heart, kidneys and liver beyond their effects on weight loss
The onset and progression of prostate cancer could be prevented by changing dietary habits by modulating nuclear factor-kappa B (NF-B), mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK), Akt, extracellular signal-regulated kinase (ERK), and phosphoinositide 3-kinases (PI3K) signaling pathways
The drug lowered levels of 2-aminoadipic acid (2-AAA), triglycerides (TGs) enriched in short- and saturated-chain fatty acids, and urate in both trial populations, while 2-hydroxybutyrate (2-HB) was lowered more robustly in the T2D cohort and mainly by week 48 in the obesity trial
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