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They found that microbial infections, such as SARS and H5N1 virus infections in the lungs, trigger NADPH-dependent ROS production, thereby generating oxidized phospholipids, such as oxidized 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine, to induce lung injury and cytokine production by lung macrophages via TLR4TRIF 80

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Lower-dose stop-short0.51.0mg/wk These doses have direct efficacy and safety data when used continuously

BPC-157 [12]

The Lys17 side chain is a C20 fatty diacid attached through a PEG2 spacer and a -glutamic acid linker