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FB1 was reported to increase induction of cytochrome P450 isoforms and caused peroxidation of membrane lipids in isolated rat liver nuclei as well as GSH depletion of in pig kidney cells [167-169]
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doi: 10.1152/ajpgi.00070.2010 136 NielsenMSAndersenINSKLangeBRitzCLe RouxCWSchmidtJBet al
The theoretical thyroid cancer risk based on rodent studies has not materialized in human populations after over a decade of clinical use, though ongoing pharmacovigilance continues
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