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2 Literature search strategy Recent literature of this narrative review was identified through searches of Web of Science Core Collection, PubMed, Science Direct, and Google Scholar using combinations of keywords related to flavonoid biosynthesis, phenylpropanoid pathway, structure-activity relationships, biotic stress, abiotic stress, combined stress, secondary metabolism, redox homeostasis, phytohormone signaling, metabolic flux, metabolic branch points, pathway competition, metabolic trade-off, multi-omics, artificial intelligence, machine learning, CRISPR/Cas systems, and metabolic engineering

Identification and expression analysis of components involved in rice Xa21 -mediated disease resistance signalling

Hepatotoxicity caused by APAP overdose is one of the leading causes of acute liver failure (ALF) in the US and in some parts of Europe, limiting its clinical application

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In addition, mTORC1 activation via glutaminolysis suppresses autophagy and the DNA damage response 164,165