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This means that 6% of the population has a deficiency symptom

Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output

10.1016/j.jmb.2014.07.015 613 WaingankarT

Although these studies did not directly measure cancer incidence, the consistent finding of impaired NK cytotoxicity in NS workers supports the experimental evidence that links circadian disruption to reduced anti-tumor immunity 107

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