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These changes encompass the 2nd, 8th, 15th, and 27th amino acids, and such adjustments might arguably extend the peptide's lifespan against enzymatic breakdown, particularly by enzymes like dipeptidyl peptidase-4 (DPP-4)

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This titration minimizes side effects, particularly the nausea and gastrointestinal discomfort that comes with GLP-1 receptor agonists