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Betaine can effectively delay the progression of fibrosis by downregulating TGF-1, alpha-smooth muscle actin ( -SMA), and collagen type I alpha 1 chain (COL1A1), regulating the balance of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1/-2, and inhibiting the activation of hepatic stellate cells (23, 125, 134136)

Molecular genetic gene-environment studies using candidate genes in schizophrenia: A systematic review