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Histochem Cell Biol
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Additionally, chronic conditions such as HIV and tuberculosis have been implicated in B12 deficiency due to increased metabolic demand and altered absorption mechanisms ( The diagnosis of vitamin B12 deficiency typically relies on low total B12 levels and elevated concentrations of homocysteine (Hcy), as well as levels of transcobalamin-bound B12 (holoTC) and methylmalonic acid (MMA), which serve as functional indicators of cobalamin insufficiency ( Vitamin B12 requirements fluctuate throughout the life course, influenced by metabolic demand and physiological changes
On a medication that already slows gastric emptying, adding a fiber that expands dramatically in the stomach can cause significant discomfort, nausea, or even exacerbate bloating symptoms
Possible explanations are the reduced viability of chondrocytes, as found by Chu et al
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