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Disruption of ABCB8 results in mitochondrial iron accumulation, oxidative stress, and cardiac dysfunction

In addition to BRCA genes, mutations in other high-penetrance genes such as TP53 (associated with Li-Fraumeni syndrome) and PTEN (linked to Cowden syndrome) have been found to be associated with familial breast cancer, as these genes are heritable, keeping women at potential risk to develop cancer during their lifetime ( PALB2, ATM , and CHEK2 (63)

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At 1 g/ml, hTERT expression was upregulated 12-fold in 21NT and at 0.5 g/ml, BT474 showed a fivefold upregulation relative to the untreated cells (Fig