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157 Additionally, activation of GLP-1R promotes the AMPK pathway, which plays a vital role in the regulation of autophagy

Melanocortins are a family of peptide hormones derived from pro-opiomelanocortin (POMC)

doi:10.1016/j.clinthera.2023.12.014

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Third, hyperglycaemia-induced PKC--specific activation in endothelial cells reduces the effect of vascular endothelial growth factor (VEGF), and ablation of PKC- in endothelial cells improves blood flow reperfusion and lateral limb angiogenesis in diabetic ischaemic limbs [45]