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However, it may also occur in dark-skinned individuals and, as described above, similar lesions can arise in sites that are never sun-exposed
It is worth noting that DMF neither affected the antitumor activity in C26, HCT116, MKN45, and MIA PaCa-2 cancer cell lines nor exacerbated the potential effects (e.g., body weight loss or bone marrow suppression) in C26-bearing mice (Miyagi et al., 2019)
Harlan notes: "Throughout the 1960s and 70s, mixing these two historically distinct types of perioral dermatitis in a discussion contributed to poor understanding both then and now