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At the end of 2016, the Amgen team filed a patent (US20170275370A1) titled "Methods for Treating or Ameliorating Metabolic Disorders Using a GIPR Binding Protein in Combination with a GLP-1 Agonist." This reported the therapeutic potential of using an antibody targeting the GIPR in combination with a GLP-1 receptor agonist for the treatment of type 2 diabetes, obesity, dyslipidemia, elevated levels of glucose, increased insulin levels, and diabetic nephropathy
( Epub 20231129 )
The animals were fed a normal-fat diet (ND, 10% fat calories) or HFD (60% fat calories) (Research Diets Inc., New Brunswick, NJ, USA) ad libitum for 8 weeks
Both are hailed as the building blocks of cellular health
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