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This iron-sequestering capability is particularly important because excess free iron directly enters cells, concentrates in mitochondria, disrupts oxidative phosphorylation, catalyzes lipid peroxidation, and ultimately leads to cell death

Besides being physiologically tailored for nerve health and deficiency correction, this particular brand has the potency that is still well tolerated by the patients

This translates to approximately 1.6 to 4 mcg per kilogram of body weight, extrapolated from effective rat doses using standard interspecies scaling factors

1 In human tissues, the distribution of glutathione also shows significant organ specificity

Since the headspace method allowed measuring the metabolism of odorants in mixtures, we tested if, as observed in drug metabolism, competitive metabolic interaction could arise between two distinct odorants, by modifying their relative perireceptor availability