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As we age, or when were exposed to stress, illness, or environmental toxins, glutathione levels can drop
Local resolution was estimated for each reconstruction using the RELION implementation of local resolution algorithm 35 , and locally scaled maps were used for model building and refinement in all cases
Paul, S., et al
In silico molecular docking further supports this, showing that Epitalon has a high binding affinity for specific histone subtypes, H1/3 and H1/6, which play a regulatory role in chromatin compaction and accessibility [4]
& Gilbert, S
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