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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management under the brand name Mounjaro and for chronic weight management as Zepbound

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Scalabrino G, Carpo M, Bamonti F, Pizzinelli S, DAvino C, Bresolin N, et al

The synergy claim is mechanistic, derived from the three peptides acting on different nodes of overlapping pathways (VEGF, NF-kB, ECM remodeling)

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