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Rdl und Partner GbR, Nrnberg

(PubMed) Cherchi A, Lai C, Angelino F, et al

The binding pocket resides the catalytic threonine at the bottom of the groove on one of the central -sheets, and it further extends into the enzyme, appearing as a finger-like projection

In a model of oligospermia, the expression of NRF2, GPX4, and FPN was significantly downregulated by busulfan exposure, and ferroptotic inhibitors reversed these changes in expression