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Sustained weight loss is better than rapid weight loss Although rapid weight loss can be appealing, losing weight too quickly can increase the risk of fatigue, nutrient deficiencies, muscle loss, and rebound weight gain
That happens sometimes with GLP-1s, since there are versions of the drug, like Ozempic, approved for type 2 diabetes but not obesity management
Protein is not optional on semaglutide
Orforglipron also reportedly has a simpler production process than injected GLP-1 drugs such as Ozempic and tirzepatide (sold as Mounjaro) and does not require cold storage factors that could help improve access to the drug if it is approved for use
Diabetes Res Clin Pract 106:e3e6 Fadini GP, Albiero M, Menegazzo L, de Kreutzenberg SV, Avogaro A (2012) The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients
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