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Zeynali, E., Soleimanzadeh, A
The mechanism of action is mediated by its binding to the GLP-1 receptor on -cells of the pancreas to stimulate insulin secretion, slow gastric emptying, and reduce postprandial glucagon secretion in a glucose-dependent fashion
Pharmacokinetics: Long acting (half life: ~1 week ) Ozempic & Wegovy : subcutaneous pen injections weekly a more favorable option for some patients compared to daily injections of short acting analogs semaglutide has a high bioavailability of ~89% when injected s.c
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In cohort studies, combination therapy was associated with a lower risk of MACE (RR 0.56 [95% CI 0.43, 0.71] and the kidney composite endpoint (RR 0.48 [95% CI 0.32, 0.73] relative to SGLT2 inhibitor or GLP-1 RA monotherapy
