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While semaglutide works incredibly well for some people, explained Amati, who was not involved in the study, its not without its downsides. You should only take it if it has been prescribed to you by a doctor in the context of a multi-disciplinary team that includes psychotherapy, physical activity, and, crucially, dietary advice. She explained why eating a good diet is particularly important: Because semaglutide reduces appetite, unless the individual consumes a healthy, diverse diet, there is a danger they might miss out on important nutrients