Liraglutide-induced cell proliferation was completely abolished by U0126, demonstrating ERK activation is important in mediating liraglutide-induced proliferation of PSCs (Figure 7d)
It plays an indirect role in the prevention of oxidative damage in cells by maintaining intracellular reduced glutathione (GSH)
half life 1.5-3 hours excreted by the kidney (no metabolism) Side Effects: Rare : dose-related incidence of lactic acidosis GI side effects (diarrhea, nausea, vomiting, abdominal bloating, gas, reduced appetite) (~20% of patients develop dose-related GI side effects) Vitamin B12 deficiency
McGovern AS, Hamlin AS, Winter G
Undershooting is fine: only 57.4% of the REDEFINE 1 combination arm was on the full dose at week 68, averaging 20.4%