Extreme caution is advised in subjects with increased risk of these severe side effects, such as those with previously diagnosed thyroid cancer or diseases of the pancreas, gallbladder, and kidneys
Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes
Independent experts caution that the findings should not be extrapolated to men with normal weight or men whose hormone problems have a different cause

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Weight regain after discontinuation is common, with studies showing 60-70% of lost weight returning within a year of stopping