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(98) Accordingly, future trials should enroll truly deficient, high-risk patients

The sample was small (10 subjects per group)

Animal data also support a protective role for adiponectin: adiponectin-deficient mice exhibit exaggerated retinal vascular permeability, increased VCAM-1 and reduced claudin-5 under hyperglycemia, whereas restoration of adiponectin signaling normalizes endothelial barrier markers and reduces leakage (216, 246)

V., Rassokhina, O