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Increased expression of VEGF stimulates angiogenesis, acting on dopamine D1 receptors, and may cause, among other things, dyskinesia, a major side effect of L-DOPA, which may further reduce the quality of life of PD patients under L-DOPA medication (Veith and Henderson 2019) Increased VEGF expression has been also documented in astrocytes, endothelial cells (ECs), and monocytes of MS patients, potentially contributing to BBB permeability and the onset of MS

Chen, E

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doi: 10.1016/j.prevetmed.2013.10.019 140 XieJ.ProudC

Gjeorgjievski M, Cappell MS