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Oral supplements face challenges in the digestive system, where absorption can be low, mainly in those with certain gut issues
Its main action is reducing the activity of tyrosinase, an enzyme responsible for melanin production
For this reason, propagated cell death should ideally be supported by multiple orthogonal criteria, including iron dependence, rescue by structurally distinct ferroptosis inhibitors, and preservation of canonical molecular hallmarks of ferroptosis
doi: 10.1002/14651858.CD004655.pub2 231
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