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The activation of non-canonical pyroptotic pathways frequently occurs upon gram-negative bacterial infection (163)
Upregulation of angiotensin II can activate NADPH oxidase enzyme complex in vascular smooth muscle cells and cardiomyocytes, further increasing the generation of ROS and participating in the progression of HF (Doughan et al., 2008)
But interesting biology and plausible mechanisms are where drug development begins, not ends
The vagus nerve registers the presence of LPS signals to these particular hypothalamic areas and cranks up body temperature, because basically it's a signal that the body is infected
Studies of quadriceps muscle crush injuries demonstrate faster restoration of myotendinous junctions and reduced fibrosis at injury sites, preserving contractile function
