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On the one hand, Stefater and colleagues showed that, during development, the stimulation of non-canonical Wnt-signaling (Wnt11 and Wnt5A) induced retinal CD11b + F4/80 + macrophages to secrete soluble VEGFR1, sequestering VEGF from the surrounding environment and thus reducing its availability for endothelial cells (53)

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doi:10.1017/S1461145707008401 Bell CJM, Mehta M, Mirza L, Young AH, Beck K