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Nutrients 10, 1031

Serious but Rare Risks GLP-1 medications can aggravate or trigger severe pancreatic inflammation in some patients. Both oral and injectable GLP-1 medications may cause gallbladder disease, and in rare cases involving patients with relevant risk factors, there have been associations with thyroid changes observed in animal studies. A serious allergic reaction is possible but uncommon

Tell your doctor if you have or have had any medical conditions, including: a disease of the spinal cord or folate-deficient megaloblastic anaemia (a type of anaemia caused by the deficiency of another vitamin called folic acid)

These drugs do not work without significant lifestyle changes

After 68 weeks, half of the participants taking Semaglutide GLP-1 had lost 15 percent of their body weight, and nearly a third had lost 20 percent