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doi: 10.1038/d41586-021-03614-z 32 CampoloJ.BernardiS.CozziL.RocchiccioliS.DellanoceC.CecchettiniA.et al
By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism
In-depth study of mechanisms of action revealed that the nanoreactors could catalyze the oxidation of GSH into GSSG
Two popular regenerative approaches
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