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In models of heart failure (HF), GLP-1 RAs have been observed to alter energy substrate utilization, alleviate myocardial and endothelial inflammation, mitigate oxidative stress, and antagonize myocardial remodeling [14]
Additionally, use of proton pump inhibitors (PPIs) and diuretics (or "water pills") such as furosemide and hydrochlorothiazide can lead to magnesium deficiency over time
The National Institute for Health and Care Excellence (NICE) provides detailed guidance on the use of DPP-4 inhibitors in type 2 diabetes through its guideline NG28 (Type 2 diabetes in adults: management), most recently updated in 2022
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