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demonstrated that blockage of the cannabinoid receptor-1 using CB1 antagonists lowered gut permeability and adipogenesis in obese mice, through normalizing Occludin and ZO-1 expression, whereas CB1 stimulation increased permeability markers both in vivo and in vitro [27]
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Optimal doses specifically for disc repair have not been established through dose-finding studies
Itoh et al., 2004
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