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Moreover, NAPstars are relatively large constructs, which may limit their targetability or usability in some subcellular locations, such as experienced for targeting Peredox to the mitochondrial matrix

The specificity of peptide-receptor interactions allows for precise modulation of biological pathways

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216 Furthermore, a randomized, double-blind, placebo-controlled trial in 65 hemodialysis patients reported that taking 1,200 mg, but not 600 mg, of CoQ10 daily for four months decreased oxidative stress (as indicated by a decrease in F2-isoprostanes)

Through binding to the relaxin family peptide receptor 1 (RXFP1), this hormone elicits multiple physiological responses including vasodilation induction, reduction of inflammation and oxidative stress, and angiogenesis stimulation