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doi: 10.1186/s13075-017-1357-2 187 LiMLiuXSunXWangZGuoWHuFet al
Weight loss begins in earnest
If your genetics show reduced GLP-1 receptor sensitivity, pharmaceutical semaglutide becomes especially valuable because it overcomes your natural limitations
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The case for considering it is straightforward: the underlying drug class (GLP-1 receptor agonists) has the strongest weight management evidence base in clinical pharmacology, supported by multiple large-scale randomized controlled trials showing 15-22% weight reduction in study populations over 68-72 weeks
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