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Smaller doses may not trigger the appetite-suppressing and metabolic effects that make the medications effective

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A 2,700-person study out of Denmark saw an average of 16% body weight loss at 64 weeks for the 20% of the participants who remained at microdose levels for the duration of the study

When Fiber Isn't Enough: Osmotic Laxatives to Know About American Journal of Gastroenterology found good evidence to recommend PEG 3350 as a first-line treatment for constipation because it is well-tolerated and generally produces few side effects